Imatinib mesylate is a small molecule that inhibits the cabl proteintyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia cml. The information provided in this material safety data sheet is correct to the best of our knowledge, information, and belief at the date of its publication. Imatinib mesylate sti571 selectively inhibits the tyrosine kinase activity of bcrabl, ckit, and pdgfr and is successfully used for treatment of bcrabldependent chronic myelogenous and acute lymphoblastic leukemia, and ckitdependent gastrointestinal stromal tumors. Take this medication by mouth with a meal and a full glass of water 8 ounces240 milliliters as directed by your doctor, usually once or twice daily. Very hazardous in case of skin contact corrosive, irritant, of eye contact irritant, of ingestion, of inhalation. Highlights of prescribing information these highlights do not include all the information needed to use gleevec safely and effectively. Store in accordance with information listed on the product insert. Lenvatinib mesylate 857890392 msds, safety technical. The pharmacological basis of this interaction has been elucidated by crystallographic studies.
Analysis of genotoxic impurities of imatinib mesylate by. Identification product name imatinib mesylate cat no. Known hypersensitivity to imatinib or any ingredient in the formulation. This document has been prepared in accordance with standards for workplace safety. Imatinib mesylate 21 is very soluble in water and soluble in aqueous buffers. The information given is designed only as a guidance for safe handling, use, processing, storage.
Imatinib mesylate safety data sheet supersedes revision. Imatinib mesylate was determined by infrared absorption spectrophotometry. Imatinib mesylate inhibition of bcrabl tyrosine kinase created. Imatinib mesylate is soluble in aqueous buffers less than or equal to ph 5. Show this safety data sheet to the doctor in attendance. Analysis of genotoxic impurities of imatinib mesylate by lcms from early development to routine monitoring.
Imatinib mesylate 50 mgkg is injected intraperitoneally in the imatinib group n7, and 0. Uses advised against food, drug, pesticide or biocidal product use. Safety data sheet imatinib mesylate effective date. Identification of the substancemixture and of the company. Imatinib, free base is a free base form of imatinib mesylate cat. Sds of imatinib mesylate, safety data sheets, cas 220127571. Material safety data sheet article 1 identification of the substance and of the companyundertaking product name. Imatinib binds to an intracellular pocket located within tyrosine kinases tk, thereby inhibiting atp binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Gleevec is often associated with edema swelling and serious fluid retention holding water. Safety data sheet creation date 03mar2016 revision date 23jan2018 revision number 3 1. Article 1 identification of the substance and of the companyundertaking. Disposition and biotransformation of imatinib were studied in four male healthy volunteers after a single oral dose of 239 mg of 14clabeled. Identification of the substancemixture and of the companyundertaking product name.
Getwell pharmaceuticals 474, udyog vihar, phasev, gurgaon 122 016, haryana, india. Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity. Patients experiencing unexpected, rapid weight gain should speak to their doctor about appropriate supportive. Imatinib mesylate syn1046 n n h n n hn o n n ch3so3h 44methyl1piperazinylm ethyln4methyl343pyridinyl2pyrimidinylaminophenylbenzamide methanesulfonate cas registry no220127571 smiles string. Efficacy and safety of imatinib mesylate in advanced. First aid providers should wear personal protective equipment to prevent exposure. Identification of the substancemixture and of the companyundertaking. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors article pdf available in new england journal of medicine 3477. Cc1ccccc1nc2ncccn2c3cccnc3nco c4ccccc4cn5ccncc5c molecular weight. Why is dailymed no longer displaying pill images on the search results and drug info pages.
Increase imatinib dosage by at least 50% and carefully monitor clinical response in patients receiving concomitant therapy with imatinib and potent cyp3a4 inducers e. Understanding the molecular basis of imatinib mesylate. Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. We conducted an openlabel, randomized, multicenter trial to evaluate the activity of imatinib in. Due to inconsistencies between the drug labels on dailymed and the pill images provided by rximage, we no longer display the rximage pill images associated with drug labels we anticipate reposting the images once we are able identify and filter out images that do not match the information provided in. Imatinib mesylate is a 2phenylaminopyrimidine tyrosine kinase inhibitor with specific activity for abl, platelet derived growth factor receptor, ckit, and albesonrelated gene. Optical activity imatinib mesylate does not have chiral centers, and it is not optically active. Imatinib mesylate sti571 is a substrate for the breast.
Imatinib mesylate is a white to offwhite to brownish or yellowish tinged crystalline powder. Lenvatinib mesylate 857890392 msds report, lenvatinib mesylate msds safety technical specifications search, lenvatinib mesylate safety information specifications ect. The information provided in this material safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Doxazosin mesylate tablets, 8mg mysidopsis bahia mysid shrimp npdes lc50 48 hours 3. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors. The dose of 25 mgkg is preliminarily tested, and it produces a little improvement in lung function without statistical significance. We collect cookies for vital website function and to better serve our customers. Ac461080050 casno 220127571 synonyms no information available recommended use laboratory chemicals. In addition, other severe fluid retention events e. The spectrum was compared with that of imatinib mesylate rs, or with a qualified reference spectrum of imatinib mesylate. Synkinasemakes no guarantee or representation, either expressed or implied, as to the accuracy or completeness of such information.
Its 20 molecular formula is c29h31n7o ch4so3 and its relative molecular mass is 589. Section 1 chemical product and company identification. Its molecular formula is c 29 h 31 n 7 o ch 4 so 3 and its molecular weight is 589. Gleevec imatinib mesylate tablets, for oral use initial u. Solubility characteristics imatinib free base is practically insoluble in water 0. Imatinib mesylate is an offwhite to creamish yellow crystalline powder. Imatinib is a potent inhibitor of the bcrabl kinase encoded by the bcrabl oncogene as well as receptor tyrosine kinases encoded by ckit and plateletderived growth factor receptor pdgfr oncogenes. Imatinib mesylate gleevec, glivec, formerly sti571 has demonstrated unprecedented efficacy as firstline therapy for treatment for all phases of chronic myelogenous leukemia and metastatic and unresectable malignant gastrointestinal stromal tumors. By continuing to browse you agree to the storing of cookies on your device. Read complete imatinib mesylate msds matnib manufactured by getwell oncology a leader manufacturing complex oncology generics in india. Sc202180 imatinib mesylate revision date 25jul2014 us federal regulations sara 3. Women should be apprised of the potential harm to the fetus 5.